Neuropathic pain is caused by a lesion or disease of somatosensory nervous system and treatment of neuropathic pain remains a challenge. The purpose of present study was to evaluate efficacy of Tolperisone, a centrally acting muscle relaxant in reducing neuropathic pain and also attempt to establish the mechanism of action of Tolperisone by comparing its effectiveness with standard drug Phenytoin. Neuropathic pain was induced in rats using Chronic Constriction Injury Model (CCIM). The Successful induction of neuropathic pain was evaluated by observing hyperalgesia and allodynia in rats exposed to various stimuli. Effectiveness of Tolperisone (10mg/kg) in treatment of Neuropathic pain was evaluated by comparing the results obtained with Standard drug Phenytoin (20mg/kg). The findings of the present study demonstrate that neuropathic pain induced using the Chronic Constriction Injury Model (CCIM) resulted in severe changes in behavioral responses producing mechanical and thermal hyperalgesia and cold-allodynia. Also our results indicate that voltage-gated sodium channel probably contributes to development of hyperalgesia and allodynia in the CCI. This study shows that Tolperisone is a potent anti-hyperalgesic and anti-allodynic compound in rats and emphasizes the concept that blockade of Na+ channels may be beneficial for pain treatment in humans.
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